Osteitis in chronic rhinosinusitis: a histopathological study of human ethmoid bone remodeling in allergic versus non-allergic chronic rhinosinusitis

Abstract

BackgroundChronic rhinosinusitis (CRS) is a disease characterized by inflammation of the mucosa lining the paranasal sinuses; however, recent evidence also indicates the involvement of the sinus bones in the inflammatory process. CRS is a disease with different phenotypes; nonetheless, the characterization of osteitis in the different CRS phenotypes is poorly characterized. Herein, we report on osteitis in two main phenotypes of CRS: a group allergic to aeroallergens who suffers from long-lasting upper airway allergy, and the CRS group with no upper airway allergy.Patients and methodology A total of 51 patients (23 females and 28 males, with a mean age of 39.03±13.4) who underwent surgery in our university hospital contributed to this study by providing bone samples from the ethmoid bone. They were divided into three groups: group I is patients who underwent septoplasty with or without partial inferior turbinectomy, and they acted as the control group; group II is patients who underwent operation for non-...