Diverse roles of Groucho/Tup1-like co-repressors in plant growth and development

Abstract

Transcriptional regulation involves coordinated and often complex interactions between activators and repressors that together dictate the temporal and spatial activity of target genes. While the study of developmental regulation has often focused on positively acting transcription factors, it is becoming increasingly clear that transcriptional repression is a key regulatory mechanism underpinning many develop- mental processes in both plants and animals. In this review, we focus on the plant Groucho (Gro)/Tup1-like co-repressors and discuss their roles in establishing the apical-basal axis of the developing embryo, maintaining the stem cell population in the shoot apex and determining floral organ identity. As well as being developmental regulators, recent studies have shown that these co-repressors play a central role in regulating auxin and jasmonate signaling pathways and are also linked to the regulation of pectin structure in the seed coat. These latest findings point to the Gro/Tup1-like co-repressors playing a much broader role in plant growth and development than previously thought, an observation that underlines the central importance of transcriptional repression in plant gene regulation. © 2012 Landes Bioscience.