ω-3 fatty acids have no impact on serum lactate levels after major gastric cancer surgery

24Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

Background: Preoperative and intraoperative nutrition support in patients undergoing major surgery results in decreased incidence of morbidity and mortality. Studies investigating the role of ω-3 fatty acids in these patients are increasing. Some are focused on perfusion at the cellular level. This study was undertaken to address the effect of postoperative administration of ω-3 fatty acids on cellular hypoperfusion associated with major gastric surgery. Methods: Twenty-six patients undergoing gastric cancer surgery were randomly assigned to receive parenteral nutrition (PN) supplemented with a combination of ω-6 and ω-3 fatty acids (Omegaven, 0.2 g/kg/d; Lipovenoes 10%, 0.6 g/kg/d) or with ω-6 fatty acid (Lipovenoes 10%, 0.8 g/kg/d) for 5 days. Blood samples were taken preoperatively, postoperative day 1, and on the last day of PN therapy (day 5). Results: Patients receiving ω-3 and ω-6 fatty acids showed neither lower serum lactate levels nor lower rates of complications compared with patients receiving ω-6 only. There were no statistically significant differences between the groups in other biochemical parameters, complications, or length of hospital stay or mortality. Conclusion: PN with ω-3 fatty acid supplementation does not have a significant impact on cellular hypoperfusion and lactate clearance after major gastric surgery. © 2011 American Society for Parenteral and Enteral Nutrition.

Cite

CITATION STYLE

APA

Makay, O., Kaya, T., Firat, O., Sozbilen, M., Caliskan, C., Gezer, G., … Ersin, S. (2011). ω-3 fatty acids have no impact on serum lactate levels after major gastric cancer surgery. Journal of Parenteral and Enteral Nutrition, 35(4), 488–492. https://doi.org/10.1177/0148607110386611

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free