Abstract
A metabolite of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was incorrectly characterized in this paper. The metabolite was thought to be an acetyl conjugate of the 5-hydroxyl-ated derivative of MeIQx. This assignment is incorrect. The correct assignment is a sulfate conjugate of 5-hydroxy-MeIQx, 2-amino-3,8-dimethylirnidazo[4,5-f]quinoxaUn-5-yl-sulfate. This conclusion is based upon repurified sample analyzed by 1H NMR and 13C NMR, enzyme hydrolysis assays, IR spectro-scopy and FAB/MS (accurate mass measurement). © 1989 IRL Press at Oxford University Press.
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Turesky, R. J., Aeschbacher, H. U., Würzner, H. P., Skipper, P. L., & Tannenbaum, S. R. (1989, September). Major routes of metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat. Carcinogenesis. https://doi.org/10.1093/carcin/10.9.1765
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