Formulation and evaluaiton of oxiconazole nitrate loaded nanosponges

Abstract

Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduced toxicity and improve patient compliance by targeting the cells and tissues to elicit the desired pharmacological action. The main aim of the study was to formulate and evaluate Oxiconazole nitrate loaded nanosponges. The oxiconazole nitrate nanosponges were prepared by the emulsion solvent diffusion method by using the different polymers (Ethyl cellulose, β-CD, HP-β-CD). The FTIR test is conducted as the preliminary test, by this test there was no interaction between the drug and polymers. Then nanosponges (NS) were evaluated for particle size, poly dispersive index (PDI), zeta potential, entrapment efficiency and invitro drug release. The particle size ranged from 480.60 to 753.46nm, PDI ranged from 0.284 to 0.502, zeta potential from -20.9 to -35.9 mV and entrapment efficiency was ranged from 52.72 to 92.72%. The cumulative percentage release from all nanosponges varied from 73.16 to 97.84 % after 12hours depending upon the drug and polymer ratio and F4 formulation showed highest drug release i.e., 97.84%. The release kinetic studies showed that the release zero order diffusion controlled and the n value (0.713) from the Korsmeyer-Peppa’s model indicated the release mechanism was non-fickian type.