Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Celiac disease exemplifies how an illness can have autoimmune-like features having to be driven by exogenous antigen and how can be reasonably considered as a model of organ-specific autoimmunity.
CITATION STYLE
López Casado, M. Á., Lorite, P., Ponce de León, C., Palomeque, T., & Torres, M. I. (2018, December 1). Celiac Disease Autoimmunity. Archivum Immunologiae et Therapiae Experimentalis. Birkhauser Verlag AG. https://doi.org/10.1007/s00005-018-0520-z
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