In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs

Abstract

This chapter reviews animal studies carried out using quorum-sensing inhibitors of Gram-negative and Gram-positive bacterial biofilm infections. Animal studies include the use of biofilm inhibitors to suppress Pseudomonas aeruginosa lung infections in mice, and the use of biofilm inhibitors to suppress antibiotic-resistant staphylococcal infections like methicillin-resistant Staphylococcus aureus in rat graft and central venous catheter models and mouse cellulitis models. The advantages of using biofilm inhibitors over those of conventional antibiotics, and the choice of inhibitor to be used are discussed.