Tetranuclear Cu(ii)-chiral complexes: Synthesis, characterization and biological activity

Abstract

Tetranuclear chiral Cu(ii)-Schiff-base complexes S-1 and R-1, were synthesised using enantiomerically pure (S)-(H2vanPheol) and (R)-(H2vanPheol) ligands respectively in the ratio of 1:1 of Cu(NO3)2 to (S/R)-(H2vanPheol) in MeOH at room temperature. A pair of polynuclear chiral Cu(ii)-cluster complexes were characterized using single-crystal X-ray diffraction, elemental analysis, infrared and CD spectroscopy. The results revealed the importance of these chiral ligands encouraging the arrangement of copper metal in non-centrosymmetric polar packing. The potential of the novel [Cu4(S/R-vanPheol)2(S/R-HvanPheol)2(CH3OH)2](NO3)2 complexes as biologically active compounds was assessed in particular regarding their anti-proliferative and anti-microbial properties.