Hyperpigmentation with Capecitabine: Part of Hand-Foot Syndrome or a Separate Entity?

Abstract

License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Capecitabine has several side effects, most common of which is Hand-Foot syndrome (HFS); however, less frequently reported is capecitabine-associated hyperpigmentation. The hyperpigmentation associated with this drug has been documented to involve the hands and feet and, less commonly, the mucous membranes of the mouth. To our knowledge, it has never been documented to involve the face. We report a case of a patient with capecitabine-induced Hand-Foot Syndrome (HFS), who also presented with hyperpigmentation of the hands, feet, oral mucosa, and face.