Sensitivity of bluetongue virus to lipid solvents, trypsin and pH changes and its serological relationship to arboviruses

Abstract

Bluetongue virus was found to be resistant to ether, chloroform and sodium deoxycholate under a variety of conditions but sensitive to treatment with trypsin. The virus had a narrow zone of pH stability between pH 6 and 8 in Michaelis buffer. Below pH 6 bluetongue was irreversibly inactivated within 1 min. at 37° C. In many of its characteristics, bluetongue virus appears to be closely related to the reoviruses. © 1966, Cambridge University Press. All rights reserved.