Thermotolerance and heat shock proteins: possible involvement of Ku autoantigen in regulating Hsp70 expression.

Abstract

Here we characterize and compare the phenomenon of thermotolerance and permanent heat resistance in mammalian cells. The biochemical and molecular mechanisms underlying the induction of thermotolerance, and the role that heat shock proteins play in its development and decay are discussed. Finally, we describe a novel constitutive HSE-binding factor (CHBF/Ku) that appears to be involved in the regulation of the heat shock response.