LDL-density-theory: Clinical trial design for aortic valve disease

Abstract

The cellular mechanisms are evolving rapidly in the field of calcific aortic valve biology. The experimental studies will have future translational implications for the treatment of this disease process. This chapter provides the premise for the role of lipids to activate atherosclerosis within the heart to initiate the development of bone formation. Lessons from the experimental studies have evolved into a series of clinical parameters, which provide the foundation for an algorithm to treat aortic valve disease: the LDL-Density-Radius and the LDL-Density-Pressure Theories. The LDL Density Theories provides a premise for the translational role of the Lrp 5/6 receptor biology in the treatment of calcific aortic valve disease.