Brain atrophy trajectories predict differential functional performance in Alzheimer's disease: Moderations with apolipoprotein E and sex

8Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

Introduction: We examine whether distinct brain atrophy patterns (using brain parenchymal fraction [BPF]) differentially predict functional performance and decline in Alzheimer's disease (AD), and are independently moderated by (1) a key AD genetic risk marker (apolipoprotein E [APOE]), (2) sex, and (3) high-risk group (women APOE ɛ4 carriers). Methods: We used a 2-year longitudinal sample of AD patients (baseline N = 170; mean age = 71.3 [9.1] years) from the Sunnybrook Dementia Study. We applied latent class analysis, latent growth modeling, and path analysis. We aimed to replicate our findings (N = 184) in the Alzheimer's Disease Neuroimaging Initiative. Results: We observed that high brain atrophy class predicted lower functional performance and steeper decline. This association was moderated by APOE, sex, and high-risk group. Baseline findings as moderated by APOE and high-risk group were replicated. Discussion: Women APOE ɛ4 carriers may selectively be at a greater risk of functional impairment with higher brain atrophy.

Cite

CITATION STYLE

APA

Sapkota, S., Ramirez, J., Yhap, V., Masellis, M., & Black, S. E. (2021). Brain atrophy trajectories predict differential functional performance in Alzheimer’s disease: Moderations with apolipoprotein E and sex. Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1). https://doi.org/10.1002/dad2.12244

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free