The present paper considers a "one-pot" green sol-gel synthesis of hybrid inorganic/organic hydrogels based on chitosan glycolate by using organically modified silica Si(OGly)4·2GlyOH as a precursor to form a network of ≡Si-O-Si≡ bonds at 4, 20, and 37°C. The gelation time of the multicomponent chitosan-containing system was estimated as a function of the composition (the polymer template and precursor concentrations, introduction of a low-molecular-weight accelerator NaCl) and gelation conditions (the pH and temperature of the sol-gel process). It has been shown that an increased polymeric salt concentration, the introduction of an accelerator, and increased pH and temperature accelerate the gel-forming process.
Shipovskaya, A. B., Malinkina, O. N., Zhuravleva, Y. Y., & Rogacheva, S. M. (2016). Synthesis of Silicon-Containing Chitosan Hydrogels in a Glycolic Acid Medium. Advances in Materials Science and Engineering, 2016. https://doi.org/10.1155/2016/3951703