The unique properties of vesicular stomatitis virus (VSV) make it a promising vaccine platform. With the advent of plasmid-based approaches to generate recombinant VSV viruses that express glycoproteins of other viruses, researchers now have the means to generate vaccine candidates targeting a variety of human pathogens. This chapter gives a general overview of the workings of VSV as a vaccine platform and provides a detailed protocol for the generation of recombinant VSV from plasmids.
CITATION STYLE
Ruedas, J. B., & Connor, J. H. (2017). Generating recombinant vesicular stomatitis viruses for use as vaccine platforms. In Methods in Molecular Biology (Vol. 1581, pp. 203–222). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6869-5_12
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