Clinical Utility of Antipeptidyl Arginine Deiminase Type 4 Antibodies

Abstract

Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are important biomarkers in the diagnosis of rheumatoid arthritis (RA) but leave a gap of > 50% seronegative in early RA(1) In addition, there is marked clinical heterogeneity in the seropositive group, precluding the use of RF and ACPA alone as prognostic biomarkers. These characteristics drive the demand for novel diagnostic and prognostic markers in RA(1).