Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first- and second-line HIV therapy and as a substitute for stavudine and zidovudine when toxicity is a problem. Although it is safe and well tolerated, a life-threatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes, especially HLA-B*5701.
CITATION STYLE
Rabie, H., Henning, K. L., Schoeman, P., De Villiers, N., Pretorius, G. H. J., & Cotton, M. F. (2009). Abacavir: Its use and hypersensitivity. Southern African Journal of HIV Medicine, (36), 81–84. https://doi.org/10.4102/sajhivmed.v10i4.265
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