New skeletal drug delivery system containing antibiotics using self-setting bioactive glass cement

Abstract

A novel device containing cephalexin as a model drug using a self-setting bioactive cement basing on Ca0-Si02-P205 glass was investigated. Glass powders contained 5% cephalexin powder hardened within 5 min after being mixed with a phosphate buffer. After hardening, in vitro drug release from homogeneous or heterogeneous drug-loaded cement pellets in a simulated body fluid at pH 7.25 and 37°C continued for more than 2 weeks. © 1992, The Pharmaceutical Society of Japan. All rights reserved.