PD-040 Risk assessment for gastrointestinal cancers in patients with family history of gastrointestinal cancer: Multi-center interim analysis study in the Republic of Korea

Abstract

Introduction: A number of personal and environmental risk factors are known to gastrointestinal (GI) cancer development. Cancer syndromes are also responsible for increased incidence of same or different cancers in involved family members. However, only a few genetic abnormalities were known to cancer syndrome.We wonder whether family history of GI cancers in first relatives has relevance to an increased risk of any GI cancer or not. But there were few studies investigating the risk of family history of GI cancers for other GI cancers. The aim of this study was to evaluate the relationship between family history of GI cancers and incidence of any GI cancer in Korean populations. Method(s): From 2015 to 2016, 476 GI cancer patients and 314 controls in 9 hospitals in the republic of Korea were included in the analysis. Personal medical histories, life styles including smoking, alcohol, physical activity and diet, and family history of GI cancers were collected with a self-administered questionnaire. A logistic regression model was evaluated to estimate the risk of developing any GI cancer. Result(s): There was no significant difference in the incidence of GI cancers between patients with family history of GI cancers and controls (p = 0.462). But patients with family history of GI cancer tended to diagnose GI cancer at earlier age than control (p = 0.04) Univariate analysis showed that older age, male gender, marital status, smoking, diabetes mellitus, chronic liver disease, parental history of GI cancer, sibling's history of GI cancer were risk factors for development of GI cancers. But, after adjusting major confounding factors, age (OR 1.079, 95% CI 1.063-1.095), male gender (OR 0.307, 95% CI 0.181-0.522) and chronic liver disease (OR 0.763, 95% CI 0.657-0.886) remained independently associated with GI cancers. In subgroup analysis of patients with esophago-gastric cancer (EG cancer), colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pancreatobiliary cancer (PB cancer), family history of GI cancer also did not show significant association. There was significant association of Hypertension with EG cancer, CRC, and PB cancer, diabetes mellitus with HCC and PB cancer, and chronic liver disease with EG cancer, CRC, HCC and PB cancer. Conclusion(s): In this interim analysis, it seems that a personal medical condition such as old age, female gender and underlying disease is more important to develop GI cancers than family history of GI cancers. Therefore, individuals with high risks for GI cancers may be better to start screening GI cancer earlier regardless of family history of GI cancers.