In order to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuates cardiopulmonary bypass (CPB)-induced cerebral damage. Male adult Beagle dogs were randomly divided into sham, control, and HBOC groups. After establishment of CPB model, hearts were arrested for 2 h and reperfused for 2 h. HBOC improved intracerebral O2 tensions and reduced the releases of biomarkers for cerebral damage, including neuron-specific enolase and S100β in both cerebrospinal fluid and serum. Moreover, HBOC attenuated the releases of tumor necrosis factor-α and interleukin-1β after CPB. Therefore, our findings suggest that HBOC could reduce cerebral damage after CPB, which was probably associated with improvement of tissue O2 preload.
CITATION STYLE
Li, Q., Li, S., Yang, Q., Li, T., Liu, J., & Yang, C. (2015). Hemoglobin-based oxygen carrier attenuates cerebral damage by improving tissue oxygen preload in a dog model of cardiopulmonary bypass. Artificial Cells, Nanomedicine and Biotechnology, 43(2), 87–92. https://doi.org/10.3109/21691401.2014.916716
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