Caspase-1 is a critical factor in the innate immune response to Legionella pneumophila. The development of methods for analyzing caspase-1 activation pathways and downstream caspase-1-associated activities has helped in understanding the regulation of this protease and the signaling components involved. Here we outline methods for directly detecting active caspase-1, measuring caspase-1 activities and analyzing components involved in the regulation of caspase-1 during L. pneumophila infection in macrophages. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Case, C. L., & Roy, C. R. (2013). Analyzing caspase-1 activation during legionella pneumophila infection in Macrophages. Methods in Molecular Biology, 954, 479–491. https://doi.org/10.1007/978-1-62703-161-5_29
Mendeley helps you to discover research relevant for your work.