NOD1 and 2 are intracellular sentinels critical to innate immunity. In this issue of Immunity, Bertrand et al. (2009) fill in a gap in the NOD signaling cascade by demonstrating that cIAP1 and 2 function as E3 ubiquitin ligases for the RIP2 signaling molecule. © 2009 Elsevier Inc. All rights reserved.
Reardon, C., & Mak, T. W. (2009, June 19). cIAP Proteins: Keystones in NOD Receptor Signal Transduction. Immunity. https://doi.org/10.1016/j.immuni.2009.06.005