Molecular genetic strategies to study gene function in mice or to generate a mouse model for a human disease are continuously under development. The application and importance of knock-in approaches are increasing. This chapter elaborates on novel developments for the generation of knock-in mice. Special emphasis is given to recombinase-mediated cassette exchange, a new emerging knock-in strategy that enables easy generation of a series of different knock-in mutations within one gene.
CITATION STYLE
Roebroek, A. J. M., Gordts, P. L. S. M., & Reekmans, S. (2011). Knock-In Approaches. In Methods in Molecular Biology (Vol. 693, pp. 257–275). Humana Press Inc. https://doi.org/10.1007/978-1-60761-974-1_15
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