The molecular pathology of head and neck squamous cell carcinoma

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a major health concern worldwide. Conventional HNSCC is associated with tobacco and alcohol use. However, a subset of HNSCC are not associated with these risk factors and are instead associated with the oncogenic high risk human papilloma virus (HPV). Conventional and HPV-positive HNSCC appear to be distinct molecular entities based on genetic profiles. This chapter reviews the clinical and pathologic features of and the molecular pathways involved in tumorigenesis of conventional and HPV-associated HNSCC. In addition, current treatment modalities and targeted therapeutics are discussed.