Lab animal models and analogies with humans

Abstract

To date, most urology studies have been obtained with the use of rodents. After today, it is certain that rodents will be used to develop treatment in the biomedical research. Traditional models have several disadvantages. For this reason, many transgenic genetically engineered models have been developed. Owing to these models, more reliable, reproducible and informative research results can be obtained. Especially in the field of urooncology, patient-derived xenograft models are applied. The development of immune deficient mice provided a rapid improvement in this area. With the development of genome editing technologies such as CRISPR-Cas9, more reliable and reproducible animal models will increase.