Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications

Abstract

Background: Diabetes mellitus is a metabolic disease that can lead to macrovascular and microvascular complications that can cause death and reduce the quality of life. The level of serum AGEs increases with diabetes or a state of hyperglycemia. Increased AGEs in patients with diabetes mellitus can increase the risk of macrovascular and microvascular complications and increase the formation of hs-CRP. This study aims to assess the differences in AGEs and hs-CRP between type 2 diabetes mellitus patients with and without complications and the relationship between AGEs and hs-CRP. Methods: A cross-sectional study was conducted with 30 subjects of type 2 diabetes mellitus with complications and 30 subjects of diabetes mellitus without complications. Data were collected from September to December 2022. AGEs were measured using ELISA and hs-CRP using the turbidimetric method. Data were statistically processed to determine the difference and relationship between AGEs and hs-CRP. Results: AGEs and hs-CRP values in patients with type 2 diabetes mellitus with complications were 0.671±0.194 ng/ mL and 2.08(0.98-15.3) mg/L. In patients with uncomplicated type 2 diabetes 0.561±0.127 ng/mL and 1.69(0.22- 9.25) mg/L. Differences in AGEs and hs-CRP between the two subject groups had significant results (AGEs p=0.012, hs-CRP p=0.038). The relationship between AGEs and hs-CRP in each subject group showed no significant results (With complications r=0.659 p=0.659, Without complications r=0.253 p=0.253). Conclusion: There are differences in AGEs and hs-CRP values between patients with type 2 diabetes mellitus with and without complications and there is no relationship between AGEs and hs-CRP values in each subject.