Novel Scintillating Nanoparticles for Potential Application in Photodynamic Cancer Therapy

4Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

The development of X-ray-absorbing scintillating nanoparticles is of high interest for solving the short penetration depth problem of visible and infrared light in photodynamic therapy (PDT). Thus, these nanoparticles are considered a promising treatment for several types of cancer. Herein, gadolinium oxide nanoparticles doped with europium ions (Gd2O3:Eu3+) were obtained by using polyvinyl alcohol as a capping agent. Hybrid silica nanoparticles decorated with europium-doped gadolinium oxide (SiO2-Gd2O3:Eu3+) were also prepared through the impregnation method. The synthesized nanoparticles were structurally characterized and tested to analyze their biocompatibility. X-ray diffraction, scanning electron microscopy, and transmission electron microscopy confirmed the high crystallinity and purity of the Gd2O3:Eu3+ particles and the homogeneous distribution of nanostructured rare earth oxides throughout the fumed silica matrix for SiO2-Gd2O3:Eu3+. Both nanoparticles displayed stable negative ζ-potentials. The photoluminescence properties of the materials were obtained using a Xe lamp as an excitation source, and they exhibited characteristic Eu3+ bands, including at 610 nm, which is the most intense transition band of this ion. Cytotoxicity studies on mouse glioblastoma GL261 cells indicated that these materials appear to be nontoxic from 10 to 500 μg·mL−1 and show a small reduction in viability in non-tumor cell lines. All these findings demonstrate their possible use as alternative materials in PDT.

References Powered by Scopus

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

75814Citations
N/AReaders
Get full text

Photodynamic therapy

5009Citations
N/AReaders
Get full text

Nanoparticles in photodynamic therapy

2557Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Systematic Review of Photodynamic Therapy in Gliomas

23Citations
N/AReaders
Get full text

Highlighted Advances in Therapies for Difficult-To-Treat Brain Tumours Such as Glioblastoma

9Citations
N/AReaders
Get full text

Potential Applications of Rare Earth Metal Nanoparticles in Biomedicine

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

da Silva, B. A., Nazarkovsky, M., Padilla-Chavarría, H. I., Mendivelso, E. A. C., Mello, H. L. de, Nogueira, C. de S. C., … Kai, J. (2022). Novel Scintillating Nanoparticles for Potential Application in Photodynamic Cancer Therapy. Pharmaceutics, 14(11). https://doi.org/10.3390/pharmaceutics14112258

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

75%

Professor / Associate Prof. 1

25%

Readers' Discipline

Tooltip

Chemistry 1

25%

Engineering 1

25%

Agricultural and Biological Sciences 1

25%

Arts and Humanities 1

25%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free