Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.
CITATION STYLE
Wing, J. B., Tay, C., & Sakaguchi, S. (2019). Control of regulatory T cells by co-signal molecules. In Advances in Experimental Medicine and Biology (Vol. 1189, pp. 179–210). Springer. https://doi.org/10.1007/978-981-32-9717-3_7
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