ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice

Abstract

Background: Hypertriglyceridemia is the most common lipid disorder with incompletely understood mechanisms. Results: ATF4 deficiency attenuates lipogenesis in the liver and protects against high fructose-induced hypertriglyceridemia in mice. Conclusion: ATF4 plays a pivotal role in regulating hepatic lipid metabolism. Significance: ATF4 is a contributing factor for the pathogenesis of hypertriglyceridemia. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.