The immune response is a dynamic multistep process with a complex system regulation. Identification of predictive biomarkers is therefore challenging. Deep investigation of an exceptional responder to pembrolizumab in ovarian cancer identifies a new mechanism of response and highlights the interest of individualized medicine strategy.
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Lheureux, S. (2018). Biomarker discovery from we to me: Is learning from each patient a new approach? Clinical Cancer Research, 24(14), 3233–3235. https://doi.org/10.1158/1078-0432.CCR-18-0380