A large number of alkaloids mimicking the structures of monosaccharides or oligosaccha- rides have been isolated from plants and microorganisms. The sugarmimicking alkaloids with a nitrogen in the ring are called azasugars or iminosugars. Naturally occurring azasugars are classified into five structural classes: polyhydroxylated piperidines, pyrrolidines, indolizidines, pyrrolizidines, and nortropanes. They are easily soluble in water because of their polyhydrox- ylated structures and inhibit glycosidases because of a structural resemblance to the sugar moiety of the natural substrate. Glycosidases are involved in a wide range of anabolic and catabolic processes, such as digestion, lysosomal catabolism of glycoconjugates, biosynthesis of glycoproteins, and the endoplasmic reticulum (ER) quality control and ER-associated degra- dation of glycoproteins. Hence, modifying or blocking these processes in vivo by inhibitors is of great interest from a therapeutic point of view. Azasugars are an important class of glycosi-
CITATION STYLE
Asano, N. (2008). Azaglycomimetics: Natural Occurrence, Biological Activity, and Application. In Glycoscience (pp. 1887–1911). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-30429-6_48
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