Reduced Rate of Hospital Admissions for ACS during Covid-19 Outbreak in Northern Italy

Abstract

Mean age (range)-yr 46 (22-74) 46 (22-74) 50 (25-73) Female sex-no. (%) 49 (57) 42 (58) 7 (50) Diagnosis of Covid-19-no. (%) Positive 59 (69) 45 (62) 14 (100) Suspected 27 (31) 27 (38) 0 Primary IMID diagnosis-no. (%) † Psoriasis 14 (16) 13 (18) 1 (7) Psoriatic arthritis 21 (24) 18 (25) 3 (21) Rheumatoid arthritis 20 (23) 14 (19) 6 (43) Ulcerative colitis 17 (20) 14 (19) 3 (21) Crohn's disease 20 (23) 19 (26) 1 (7) Ankylosing spondylitis 9 (10) 9 (12) 0 BMI ‡ 27.4±6 26.7±5 30.8±8 Coexisting conditions-no. (%) History of organ transplantation 1 (1) 1 (1) 0 Congestive heart failure 1 (1) 1 (1) 0 Hypertension 11 (13) 6 (8) 5 (36) Diabetes 5 (6) 3 (4) 2 (14) Chronic obstructive pulmonary disease 4 (5) 3 (4) 1 (7) Asthma 15 (17) 15 (21) 0 Currently pregnant 2 (2) 1 (1) 1 (7) Long-term medications-no. (%) ACE inhibitor or ARB 13 (15) 8 (11) 5 (36) Any medication for primary IMID diagnosis 75 (87) 62 (86) 13 (93) Methotrexate 17 (20) 11 (15) 6 (43) Hydroxychloroquine 8 (9) 5 (7) 3 (21) Oral glucocorticoids 8 (9) 4 (6) 4 (29) Any biologic or JAK inhibitor 62 (72) 55 (76) 7 (50) Tumor necrosis factor inhibitor 38 (44) 35 (49) 3 (21) Interleukin-17 blocker 6 (7) 5 (7) 1 (7) Interleukin-23 blocker 3 (3) 3 (4) 0 Interleukin-12/23 blocker 6 (7) 6 (8) 0 JAK inhibitor 6 (7) 5 (7) 1 (7) Covid-19 symptoms-no. (%) Fever 72 (84) 60 (83) 12 (86) Cough 36 (42) 24 (33) 12 (86) Shortness of breath 35 (41) 22 (31) 13 (93) Rhinorrhea 5 (6) 4 (6) 1 (7) Sore throat 9 (10) 9 (12) 0 Diarrhea 13 (15) 9 (12) 4 (29) The New England Journal of Medicine Downloaded from nejm.org on August 27, 2020. For personal use only. No other uses without permission.