Two Different Tests for Total Bilirubin in Neonates and Infants

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Background: The most readily available methods for testing serum total bilirubin in neonates are the capillary tube-directed optics color method and serum biochemistry. Because inconsistency between these two methods may cause confusion in clinical practice, this study was designed to quantify their differences. Methods: In 46 neonates with clinical jaundice, total bilirubin was measured by two different methods, using a nonchemical photometric device and a laboratory analyzer. Results: Differences in results between these two methods were statistically significant, especially when total bilirubin level exceeded 15 mg/dL. Conclusion: Clinicians should be aware of the differences between the two methods when making decisions in patient care. © 2009 Taiwan Pediatric Association.




Chen, S. D., Wang, C. M., Lee, W. L., Wang, W. C., & Chen, C. J. (2009). Two Different Tests for Total Bilirubin in Neonates and Infants. Pediatrics and Neonatology, 50(6), 291–293.

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