Emergence of multidrug-resistance in tuberculosis cases: Role of risk factors

  • Bompelli A
  • Konuru V
Citations of this article
Mendeley users who have this article in their library.


Background: In 2013, 6.1 million tuberculosis (TB) cases were reported to WHO. Of these, 5.7 million were people newly diagnosed and another 0.4 million were already on treatment. Globally, 3.5% of new and 20.5% of previously treated TB cases were estimated to have had multidrug resistant (MDR) - TB. The previous treatment for TB is the strongest risk factor for development of MDR-TB. The current scenario states that even treatment naive patients are also at risk. Methods & Materials: The study was a prospective observational study aimed to identify the group at high risk was carried out over a period of 9 months in govt. hospitals in the Telangana region. The patients were enrolled based on the MDR-TB suspect criteria: failure, S+ at 4th month (retreatment case), contact of known MDR-TB case, S+ at diagnosis (retreatment case), any follow up S+, S- at diagnosis (retreatment case), and HIV-TB case. Results were analyzed using fisher's exact test. Results: Among 2033 suspected MDR-TB patients, 453 (22%) showed resistance to isoniazid/rifampicin or isoniazid and rifampicin. Out of 453, 199 (43%) were resistant to Isoniazid, 173 (38%) were resistant to both Isoniazid and rifampicin, and 81 (17%) were resistant to rifampicin. Patients aging <45 years (76%) and >45 years (23%) were found to be at equal risk (p=0.085). Analyzing 453 MDR-TB cases, males (78%) were found to be at higher risk to develop MDR-TB (p=0.002). But if we consider the whole suspect population (2033), out of 1641 male suspected cases, 355 (21%) were diagnosed with MDR-TB and out of 392 female suspected cases, 98 (25%) were diagnosed with MDR-TB. This clearly states that both genders are at equal risk. Among 453 suspected cases, S+ at diagnosis-retreatment case (291) were found to be at high risk followed by any follow up S+ (84) and HIV TB case (32). Conclusion: The study concluded that each and every suspect individual is at equal risk to develop MDR-TB. The high level of significance in risk of developing MDR-TB directs this study further to check for the strategies to reduce the rate of TB and MDR.




Bompelli, A., & Konuru, V. (2016). Emergence of multidrug-resistance in tuberculosis cases: Role of risk factors. International Journal of Infectious Diseases, 45, 220. https://doi.org/10.1016/j.ijid.2016.02.498

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free