SP129RENAL FUNCTION AND METABOLIC PROFILE IMPROVEMENT AFTER CIRCUIT TRAINING PHYSICAL ACTIVITY AMONG HIV PATIENTS

Abstract

INTRODUCTION AND AIMS: HIV is a worldwide public health problem and is frequently associated with kidney injury. The aim of this study is to investigate the effect of a physical exercise training on renal function and lipid profile among HIV-infected patients. METHODS: This is a prospective study with HIV patients attending a reference Infectious Diseases Outpatients' Clinics in Fortaleza metropolitan area, Northeast Brazil. Patients older than 18 years and using antiretrovirals for at least 36 months were included. They were randomized to either an exercise group (EIG) or a non-exercising control group (CG) for comparative analysis. Patients in the EIG participated in a circuit training program over the course of 8 weeks. It consisted in training sessions 3 times a week lasting 50-60 minutes. The training classes were divided into heating (5 to 10 minutes), main training (35 to 45 minutes) and calm (5 minutes). The main training consisted of the circuit training method, in which 3 laps were performed, each with 6 exercises in sequence. Anthropometry and laboratory tests were done before and after the 8-weeks period. RESULTS: A total of 90 patients accepted to participate in the study and signed the consent form; 45 were randomized to EIG and 45 to GC. After 8 weeks, 30 patients were lost to follow-up. Male predominance was observed in the EIG (78.1%). The majority of patients had low income and complete high school. The initial physical and laboratory data from the control and intervention groups were similar in both groups, except for of BMI levels, which were significantly lower in the EIG (p<0.05). After the intervention there were significant differences in other parameters between the two groups, including body fat, waist circumference, HDL, LDL, triglycerides, urea, glucose and hemoglobin. The comparison of these parameters before and after the intervention showed mild differences in the control group and significant differences in the intervention group, with improvement in almost all parameters, including renal function (creatinine: 0.9860.1 vs. 0.8560.1mg/dL, before and after, respectively) and metabolic profile, with improvement in glucose, HDL and LDL levels. CONCLUSIONS: This is the first study to investigate the effects of physical activity (circuit training) in HIV-infected patients in our region. We have evidenced that physical exercise brings important improvement to these patients, including better body composition and laboratory profile. There was significant improvement in the levels of lipids, glucose, urea, creatinine, evidencing a positive metabolic effect of physical exercise.