High risk of developing subsequent epilepsy in young adults with migraine: A nationwide population-based cohort study in Taiwan

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Abstract

Background and purpose: This study evaluated the effect of migraine on the subsequent development of epilepsy. Methods: A total of 10 016 patients diagnosed with migraine [ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) 346] during the period between 2000 and 2009 who were aged older than 20 years were identified as the migraine cohort. A comparison cohort including 40 064 people were enrolled in this study. We calculated the adjusted hazard ratio (aHR) for developing epilepsy (ICD-9-CM 345) in the two cohorts after adjusting for age, sex and comorbidities. Kaplan- Meier analysis was used to measure the cumulative epilepsy incidence, and the log-rank test was used to estimate the differences between two curves. Results: The cumulative incidence of epilepsy was significantly high in the migraine cohort. The aHR for developing epilepsy in the migraine cohort was 1.85 (95% CI = 1.22-2.81). The aHR for developing epilepsy in the female migraineurs was significantly different compared with that of the non-migraine cohort (aHR = 2.04, 95% CI = 1.20-3.48) and male migraineurs (aHR = 1.53, 95% CI = 0.78- 3.00). The incidence of developing epilepsy was increased in patients aged 20-44 years, yielding an aHR of 2.14 (95% CI = 1.24-3.68). The comorbidity- specific aHR for developing epilepsy associated with migraine was 2.33 (95% CI = 1.25-4.34) in patients without any comorbidities, and 1.73 (95% CI = 1.02-2.93) in those with comorbidities. Conclusion: This population-based retrospective cohort study revealed a significant increase in subsequent epilepsy risk in young adults with migraine.

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Harnod, T., Wang, Y. C., & Kao, C. H. (2015). High risk of developing subsequent epilepsy in young adults with migraine: A nationwide population-based cohort study in Taiwan. QJM: An International Journal of Medicine , 108(6), 449–455. https://doi.org/10.1093/qjmed/hcu215

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