Optimizing polyplexes into synthetic viruses for tumor-targeted gene therapy

Abstract

5 Conclusions: Receptor-targeted polyplex systems have been established that display encouraging in vivo activity. In particular, systemic targeting of distant tumors was demonstrated, and therapeutic effects have been obtained in several mouse tumor models. In the future, polyplexes have to be developed into virus-like complexes, consisting of biodegradable materials and designed to contain bioresponsive elements that present virus-like delivery functions in a controlled manner.