An intramolecular, alkyne Prins type cyclization of vinylogous carbonates derived from o-alkynyl phenols is developed for the stereoselective construction of trans-2,3-disubstituted dihydrobenzofuran derivatives. Strong Lewis acids like TMSOTf catalyse this reaction efficiently. The presence of mildly electron donating groups on aryl rings increases the efficiency of the reaction. © Indian Academy of Sciences.
CITATION STYLE
Gharpure, S. J., & Prasath, V. (2011). Stereoselective synthesis of 2,3-disubstituted dihydrobenzofuran using alkyne Prins type cyclization to vinylogous carbonates. Journal of Chemical Sciences, 123(6), 943–949. https://doi.org/10.1007/s12039-011-0162-8
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