The CAS neonatal NIRS system determines absolute regional brain tissue oxygen saturation (SnO2) and brain true venous oxygen saturation (SnvO2) non-invasively. Since NIRS-interrogated tissue contains both arterial and venous blood from arterioles, venules, and capillaries, SnO 2 is a mixed oxygen saturation parameter, having values between arterial oxygen saturation (SaO2) and cerebral venous oxygen saturation (SvO2). To determine a reference for SnO2, the relative contribution of SvO2 to SaO2 drawn from a brain venous site vs. systemic SaO2 is approximately 70:30 (SvO 2:SaO2). If the relationship of the relative average contribution of SvO2 and SaO2 is known and does not change to a large degree, then NIRS true venous oxygen saturation, SnvO2, can be determined non-invasively using SnO2 along with SaO 2 from a pulse oximeter.
CITATION STYLE
Benni, P. B., Chen, B., Dykes, F. D., Wagoner, S. F., Heard, M., Tanner, A. J., … Short, B. L. (2005). Validation of the CAS neonatal NIRS system by monitoring VV-ECMO patients: Preliminary results. In Advances in Experimental Medicine and Biology (Vol. 566, pp. 195–201). https://doi.org/10.1007/0-387-26206-7_27
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