Cardiac electrophysiological effects of nitric oxide

N/ACitations
Citations of this article
83Readers
Mendeley users who have this article in their library.

Abstract

Nitric oxide (NO) synthetized by essentially all cardiac cell types plays a key role in the regulation of cardiac function. Recent evidence shows that NO modulates the activity of cardiac ion channels implicated in the genesis of the cardiac action potential and exerts anti-arrhythmic properties under some circumstances. We review the effects of NO on cardiac ion channels and the signalling pathways, including cGMP-dependent (protein kinase G and cGMP-regulated phosphodiesterases) and cGMP-independent mechanisms (S-nitrosylation and direct effects on G proteins) and finally the role of NO in the genesis of cardiac arrhythmias during ischemia-reperfusion, heart failure, long QT syndrome, atrial fibrillation, and sudden cardiac death. © 2010 The Author.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Tamargo, J., Caballero, R., Gómez, R., & Delpón, E. (2010, September 1). Cardiac electrophysiological effects of nitric oxide. Cardiovascular Research. https://doi.org/10.1093/cvr/cvq214

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 27

43%

Researcher 20

32%

Professor / Associate Prof. 14

22%

Lecturer / Post doc 2

3%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 25

42%

Medicine and Dentistry 22

37%

Biochemistry, Genetics and Molecular Bi... 7

12%

Pharmacology, Toxicology and Pharmaceut... 6

10%

Save time finding and organizing research with Mendeley

Sign up for free