Hesperetin glucuronides induce adipocyte differentiation via activation and expression of peroxisome proliferator-activated receptor-γ

14Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

In previous reports, hesperidin, a flavonoid glucoside from citrus fruit, is hydrolyzed to hesperetin, an aglycone of hesperidin, and converted to the hesperetin glucuronides (H7-OG and H3′-OG) in vivo and depresses blood glucose levels. But there are no reports on the activity of hesperetin glucuronides. To determine the activity of hesperetin glucuronides, H7-OG and H3′-OG were synthesized and peroxisome proliferator-activated receptor-γ (PPARγ) agonist activity was observed at 250 μM. These glucuronides accelerated the differentiation of 3T3- L1 cells into adipocytes at 10 μM. Furthermore, H7- OG showed additive effects in reporter gene assays and caused noncompetitive reactions in timeresolved fluorescence resonance energy transfer assays with a thiazolidinedione derivative. Our results indicated that hesperetin glucuronides activated PPARγ, accelerated adipocyte differentiation.

Author supplied keywords

Cite

CITATION STYLE

APA

Gamo, K., Miyachi, H., Nakamura, K., & Matsuura, N. (2014). Hesperetin glucuronides induce adipocyte differentiation via activation and expression of peroxisome proliferator-activated receptor-γ. Bioscience, Biotechnology and Biochemistry, 78(6), 1052–1059. https://doi.org/10.1080/09168451.2014.910097

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free