Scientific basis of ayurvedic medicine: In hunt for a cure to Alzheimer's disease

Abstract

Alzheimer's disease (AD) is a degenerative brain disorder that manifests as a progressive deterioration of memory and mental function-a state of mind commonly referred as "dementia"-and causes changes in personality and behavior. AD was first described in 1906 by the German neuropsychiatrist Prof. Alois Alzheimer. Major pathological hallmarks of AD are characterized by deposition of abnormal amyloid β-protein plaques and formation of neurofibrillary tangles of tau protein and decline in cholinergic neurotransmission in the brain. Amid a decade ago, huge development in Alzheimer's pervasiveness has lighted the significance of more examines in the inquiry of new prescription. One of the major clinical advances in the treatment of AD has been the utilization of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors to mitigate ACh level in the cerebrum albeit cholinergic compounds with nicotinic and muscarinic agonist properties additionally have pulled in some intrigue. At present, there are extremely constrained meds accessible to treat AD, and a large portion of the treatment is accessible just to defer the movement of side effects and symptomatic alleviation for a brief timeframe. Medicinal plants have a lot of undiscovered store of regular medications and potential wellspring of common AChE inhibitors. The basic assorted variety of their phytoconstituents makes them a significant wellspring of novel lead mixes for the mission of medications to treat AD. In this way, orderly ethnopharmacological screening of these plants may give valuable leads in the disclosure of new medications for AD treatment. With this foundation, an efficient survey is set up to deliver a refreshed learning in different phytoextracts and their subordinates alongside their conceivable activity on cholinergic sensory system to ease AD treatment. Electronic database was utilized for looking through the data identified with studies performed in plants amid decades ago.