Risk Factor for a Residual Deep Vein Thrombosis after Fondaparinux Administration in Patient with Postoperative Replacement Arthroplasty

Abstract

Deep venous thrombosis (DVT) is a life-threatening postoperative complication and occurs frequently after totalknee-replacement arthroplasty (TKA) and total-hip-replacement arthroplasty (THA). Fondaparinux (FPX) has been used to treat and prevent DVT, however interindividual difference of the drug e <0.02). Multivariate logistic regression analysis revealed that APTT lower than 28.5 seconds on POD1 was considered to be independent risk factor significantly contributing to residual DVT (odds ratio 17.5, 95% confidential interval 2.0-295.4, p=0.02). These findings should provide useful information for understanding the interindividual difference of the e