Evaluation of the correlation between amount of curcumin intake and its physiological effects in rats

Abstract

We examined the correlation between amount of curcumin intake and its physiological effects on indices of liver function, serum and liver lipid profiles in rats. Animals were fed diets containing 0.5, 5 and 50 mg curcumin per 100 g body weight for 28 days. HDL-cholesterol concentrations of rats fed curcumin diets were significantly higher (P < 0.05) than those of the control group, and serum TG concentration of rats fed the x100 curcumin diets was significantly lower (P < 0.05) than that of the x1 curcumin group. Serum TG concentration of rats fed curcumin diets tended to decrease in a curcumin dose-dependent manner. These results indicate that curcumin intake can improve serum lipid profiles effectively.