Motion-corrected 23Na MRI of the human brain using interleaved 1H 3D navigator images

Abstract

Purpose: To evaluate the feasibility of motion correction for sodium (23Na) MRI based on interleaved acquired 3D proton (1H) navigator images. Methods: A 3D radial density-adapted sequence for interleaved 23Na/1H MRI was implemented on a 7 Tesla whole-body MRI system. The 1H data obtained during the 23Na acquisition were used to reconstruct 140 navigator image volumes with a nominal spatial resolution of (2.5 mm)3 and a temporal resolution of 6 s. The motion information received from co-registration was then used to correct the 23Na image dataset, which also had a nominal spatial resolution of (2.5 mm)3. The approach was evaluated on six healthy volunteers, whose motion during the scans had different intensities and characteristics. Results: Interleaved acquisition of two nuclei did not show any relevant influence on image quality (SNR of 13.0 for interleaved versus 13.2 for standard 23Na MRI and 176.4 for interleaved versus 178.0 for standard 1H MRI). The applied motion correction increased the consistency between two consecutive scans for all examined volunteers and improved the image quality for all kinds of motion. The SD of the differences ranged between 2.30% and 6.96% for the uncorrected and between 2.13% and 2.67% for the corrected images. Conclusion: The feasibility of interleaved acquired 1H navigator images to be used for retrospective motion correction of 23Na images was successfully demonstrated. The approach neither affected the 23Na image quality nor elongated the scan time and can therefore be an important tool to improve the accuracy of quantitative 23Na MRI.