Apolipoprotein AI-CIII gene polymorphisms in Japanese myocardial infarction survivors

Abstract

To search for a linkage marker for the putative deleterious atherogenic gene in the apo AI-CIII-AIV gene complex in Japanese, apo CIII Sst-I genotypes and apo AI Msp-I genotypes were investigated in 69 Japanese myocardial infarction survivors, using genomic hybridization analysis, and compared with the genotypes in 82 healthy subjects. Unlike the association of the S2 and M2 alleles with myocardial infarction found in Caucasians, there were no differences in both the frequencies of the S2 and M2 alleles between Japanese myocardial infarction survivors and healthy subjects. The individual with the haplotype S1-M2, however, was significantly increased in myocardial infarction survivors compared with the one in healthy subjects (24%versus 11%; χ2=4.90, d.f.=1, p<0.05). The data suggest that the haplotype S1-M2 may be a linkage marker for the putative atherogenic gene or may show regional differences in the frequency in Japanese. © 1987 The Japan Society of Human Genetics.