Oils’ impact on comprehensive fatty acid analysis and their metabolites in rats

7Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

Fatty acids, especially polyunsaturated, and their metabolites (eicosanoids) play many pivotal roles in human body, influencing various physiological and pathological processes. The aim of the study was to evaluate the effect of supplementation with edible oils diverse in terms of fatty acid composition on fatty acid contents, activities of converting their enzymes, and on lipoxygenase metabolites of arachidonic and linoleic acids (eicosanoids) in rat serum. Female Sprague-Dawley rats divided into seven groups were used in the study. Animals from six groups were fed one of oils daily (carotino oil, made up by combining of red palm oil and canola oil, linseed oil, olive oil, rice oil, sesame oil, or sunflower oil). One group received a standard diet only. Fatty acids were determined using gas chromatography with flame ionization detection. Eicosanoids— hydroxyeicosatetraenoic (HETE) and hydroxyoctadecadienoic acids (HODE) were extracted using a solid-phase extraction method and analyzed with HPLC. Vegetable oils given daily to rats caused significant changes in serum fatty acid profile and eicosanoid concentrations. Significant differences were also found in desaturases’ activity, with the linseed and olive oil supplemented groups characterized by the highest D6D and D5D activity. These findings may play a significant role in various pathological states.

Cited by Powered by Scopus

Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health

33Citations
N/AReaders
Get full text

Profiles of Fatty Acids, Polyphenols, Sterols, and Tocopherols and Scavenging Property of Mediterranean Oils: New Sources of Dietary Nutrients for the Prevention of Age-related Diseases

8Citations
N/AReaders
Get full text

Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines

5Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Stawarska, A., Jelińska, M., Czaja, J., Pacześniak, E., & Bobrowska-Korczak, B. (2020). Oils’ impact on comprehensive fatty acid analysis and their metabolites in rats. Nutrients, 12(5). https://doi.org/10.3390/nu12051232

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

58%

Researcher 4

33%

Lecturer / Post doc 1

8%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 3

33%

Nursing and Health Professions 2

22%

Engineering 2

22%

Biochemistry, Genetics and Molecular Bi... 2

22%

Save time finding and organizing research with Mendeley

Sign up for free