Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging

Abstract

The regenerative capabilities of a living organism is determined by the ability and potential of its stem cells to replace damaged tissue or worn-out cells; therefore, all ageing phenomena, including tissue deterioration, cancer, and propensity to infections, can be interpreted as signs of ageing at the level of somatic stem cells. Understanding the molecular mechanisms underlying stem cell ageing and utilizing technological methods for regenerating stem cells enable us to develop effective treatment for large spectrum of age-associated disorders. The application of human pluripotent stem cells for the treatment of a wide variety of age-associated diseases requires the development of technologies to finely regulate their growth and differentiation.