Koi herpesvirus disease

Abstract

Koi herpesvirus (KHV) disease caused by cyprinid herpesvirus 3 (CyHV-3) affects carp Cyprinus carpio and its varieties. The disease is listed by the OIE and is also designated as "Specific diseases" in a Japanese law. In Japan, the disease first occurred in 2003 and has quickly spread to all prefectures by distributing infected fish. This review describes basic information on KHV/KHV disease such as its pathogenicity, diagnostic methods, control measures and status of virus distribution in Japan.