A synthesis method of gene networks having cyclic expression pattern sequences by network learning

Abstract

Recently, the synthesis of gene networks having desired functions has become of interest to many researchers and several studies have been done. Synthesis methods of gene networks possessing desired expression pattern sequences are proposed. Periodic phenomena, e.g. circadian rhythm, are the important functions of cells. In this paper, we consider a synthesis problem of gene networks possessing the desired persistent cyclic expression pattern sequences. We have proposed the synthesis method of gene networks possessing the desired expression pattern sequences. Desired cyclic expression pattern sequences can be realized by using the synthesis method. But the behavior may not be persistent. We derive a sufficient condition such that the desired cyclic expression pattern sequences are persistent and propose a synthesis method realizing the persistent desired behavior by network learning. © 2009 Springer-Verlag Berlin Heidelberg.